Caister Academic Press

Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol. 1)

"intended for a wide audience" Ref. Res. Book News
Publisher: Caister Academic Press
Edited by: Matthias J. Reddehase
Institute for Virology, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany
Pages: xxiv + 464
Publication date: April 2013
ISBN: 978-1-908230-19-5
Price: GB £219 or US $399Buy book or Buy online
Publication date: October 2013
ISBN: 9781912530366
Price: US $399Buy ebook
Supplementary material

See also: Volume 2

Human Cytomegalovirus (CMV), a member of the herpesvirus family, is an under-rated health risk. Low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune system is intact, with primary infection thus usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with life-long neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immunocompromised patients requiring either a solid organ graft or receiving a hematopoietic cell graft for the treatment of hematopoietic malignancies that are refractory to standard therapies. Under the condition of weakened immune surveillance in these patients, latent CMV hidden in transplanted donor cells or in the recipients' own tissues can awake to cause a destructive infection resulting in graft loss and multiple end-organ disease, of which viral pneumonia is the most feared.

Volume 1 of a two-volume work that is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models.

The book is liberally illustrated with figures, most of which are in full colour. There are many tables and plentiful references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities.


"intended for a wide audience of virologists, clinicians in intensive care medicine and transplantation centres, researchers involved with antiviral drug and vaccine development, and public health and science funding authorities" from Ref. Res. Book News (June 2013).

Table of contents
I.1. Comparative Genomics of Primate Cytomegaloviruses
Andrew J. Davison, Mary Holton, Aidan Dolan, Derrick J. Dargan, Derek Gatherer and Gary S. Hayward
I.2. Molecular Evolution of Murine Cytomegalovirus Genomes
Alec J. Redwood, Geoffrey R. Shellam and Lee M. Smith
I.3. Manipulating CMV Genomes by BAC Mutagenesis: Strategies and Applications
Zsolt Ruzsics, Eva M. Borst, Jens B. Bosse, Wolfram Brune and Martin Messerle
I.4. Human Cytomegalovirus Metabolomics
Joshua D. Rabinowitz and Thomas Shenk
I.5. Cytomegalovirus-encoded miRNAs
Meaghan H. Hancock, Igor Landais, Lauren M. Hook, Finn Grey, Rebecca Tirabassi and Jay A. Nelson
I.6. Cytomegalovirus Proteomics
Patrizia Caposio, Daniel N. Streblow and Jay A. Nelson
I.7. A Systems Pathway View of Cytomegalovirus Infection
Peter Ghazal, Alexander Mazein, Steven Watterson, Ana Angulo and Kai A. Kropp
I.8. Virus Entry and Activation of Innate Defense
Adam L. Feire and Teresa Compton
I.9. Pre-immediate Early Tegument Protein Functions
Robert F. Kalejta
I.10. Major Immediate-Early Enhancer and Its Gene Products
Jeffery L. Meier and Mark F. Stinski
I.11. Multifaceted Regulation of Human Cytomegalovirus Gene Expression
Marco Thomas, Nina Reuter and Thomas Stamminger
I.12. Intracellular Sorting and Trafficking of Cytomegalovirus Proteins during Permissive Infection
Anamaris M. Colberg-Poley and Chad D. Williamson
I.13. Morphogenesis of the Cytomegalovirus Virion and Subviral Particles
Wade Gibson and Elke Bogner
I.14. Exploitation of Host Cell Cycle Regulatory Pathways by HCMV
Deborah H. Spector
I.15. Cell Death Pathways Controlled by Cytomegaloviruses
A. Louise McCormick and Edward S. Mocarski
I.16. Cytomegaloviruses and Interferons
Mirko Trilling and Hartmut Hengel
I.17. Cytomegalovirus Inter-Strain Variance in Cell-Type Tropism
Barbara Adler and Christian Sinzger
I.18. Molecular Basis of Cytomegalovirus Host Species Specificity
Wolfram Brune
I.19. Epigenetic Regulation of Human Cytomegalovirus Gene Expression: Impact on Latency and Reactivation
Matthew Reeves and John Sinclair
I.20. Transcription Associated with Human Cytomegalovirus Latency
Barry Slobedman, Selmir Avdic and Allison Abendroth
I.21. Myeloid Cell Recruitment and Function in Cytomegalovirus Dissemination and Immunity
Lisa P. Daley-Bauer and Edward S. Mocarski
I.22. Immune Surveillance of Cytomegalovirus Latency and Reactivation in Murine Models: Link to 'Memory Inflation'
Christof K. Seckert, Marion Grieβl, Julia K. Büttner, Kirsten Freitag, Niels A.W. Lemmermann, Mary A. Hummel, Xue-Feng Liu, Michael I. Abecassis, Ana Angulo, Martin Messerle, Charles H. Cook and Matthias J. Reddehase
I.23. Humanized Mouse Models of Cytomegalovirus Pathogenesis and Latency
M. Shane Smith, Daniel N. Streblow, Patrizia Caposio, and Jay A. Nelson

How to buy this book

(EAN: 9781908230195 9781912530366 Subjects: [microbiology] [virology] [medical microbiology] [genomics] )