The Influence of Gut Microbiota's Composition on the Carcinogenesis of Gastrointestinal Tract Cancers
Vo Phuoc Tuan, Boldbaatar Gantuya, Takashi Matsumoto and Yoshio Yamaoka
from: Microbiota: Current Research and Emerging Trends (Edited by: Takashi Matsumoto and Yoshio Yamaoka,). Caister Academic Press, U.K. (2019) Pages: 99-122.
Interest in the role of microbiota in human health has increased over the last several decades. Current advanced techniques have made it possible to study the compositions and the functions of microbial communities in humans, especially in the gastrointestinal tract where the majority of bacteria reside. The disturbances of these communities, so-called "dysbiosis", have been implicated to be associated with gastrointestinal tract cancers; however, the patterns or the role of the dysbiosis are still not yet fully understood. Recently, several microbiota-based therapeutic approaches have been developed; however, the ability to apply as well as the efficacy of these treatments in clinical practice have still remained to be controversial. From this context, this chapter aims to summarize the recent findings, focusing on the bacterial dysbiosis in the gastrointestinal tract, particularly in the oesophagus, stomach and colon and we discuss their roles in carcinogenesis. In addition, we describe the potential application of therapeutic targeting microbiota and discuss the future trend of microbiota studies read more ...