Caister Academic Press

Beneficial Effects of Probiotics for Infants and Children with Dysbiosis

Yuichiro Yamashiro, Hiromichi Shoji, Naoto Nishizaki and Satoru Nagata
from: Microbiota: Current Research and Emerging Trends (Edited by: Takashi Matsumoto and Yoshio Yamaoka,). Caister Academic Press, U.K. (2019) Pages: 45-54.


Epidemiological studies have established a clear correlation between factors that disrupt the intestinal bacterial community (dysbiosis) early in life, and diseases and metabolic conditions associated with altered development of the immune system. Recent studies have also described interventions that modify host microbial composition, suggesting that overcoming microbial imbalances during childhood may serve as a preventive therapeutic approach. Probiotics are defined as live microorganisms that, when taken in a sufficient amount, have a benefit for the ingesting host. The use of probiotics is one approach to preventing and regulating dysbiosis in infants and children. The biomedical literature has recently featured an increasing number of prospective, randomized, controlled trials indicating that probiotics can be employed as an effective strategy for the treatment of a variety of diseases affecting children. This review will focus on systematic reviews highlighting the efficacy of probiotics in treating pediatric illnesses such as pre-term low-birth-weight infants with necrotizing enterocolitis and infection, infants born by caesarean section with allergy, children with mucositis, and children with obesity. Our own trial testing a probiotic supplement for use by healthy children also will be described read more ...
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