Caister Academic Press

Dysbiosis in Infants is an Important Environmental Factor of Developmental Origins of Health and Disease

Yuichiro Yamashiro, Ravinder Nagpal, Hiromichi Shoji, Naoto Nishizaki and Satoru Nagata
from: Microbiota: Current Research and Emerging Trends (Edited by: Takashi Matsumoto and Yoshio Yamaoka,). Caister Academic Press, U.K. (2019) Pages: 32-44.


The original concept of the developmental origins of health and disease (DOHaD) was 'fetal origins of adult disease' but it is now revised as that 'early life environmental factors can have lifelong effects, and can manifest as disease in later life', based on the subsequent various studies. Recent studies demonstrated that gut microbiota plays an important role in human health and disease development. In particular, the aberrant bacterial community (dysbiosis) in early life can lead to diseases, such as noncommunicable diseases, through an altered development of the immune system and metabolic condition. Therefore, the microbiota should be considered as an important environmental factor for DOHaD read more ...
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