Molecular Biology of Animal Herpesviruses
Thomas C. Mettenleiter, Günther M. Keil and Walter Fuchs
from: Animal Viruses: Molecular Biology (Edited by: Thomas C. Mettenleiter and Francisco Sobrino). Caister Academic Press, U.K. (2008)
Herpesviruses are highly successful pathogens infecting animals and man. Although there is a wide variety of different herpesviruses with different biological characteristics, they have in common basic properties such as morphology of the virion, highly regulated transcription and establishment of latency. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Research on pseudorabies virus, the causative agent of Aujeszky's disease in pigs, has pioneered animal disease control with genetically modified vaccines. PrV is now extensively studied as a model for basic processes during lytic herpesvirus infection, and for unravelling molecular mechanisms of herpesvirus neurotropism, whereas bovine herpesvirus 1, the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis, is analyzed to elucidate molecular mechanisms of latency. The avian infectious laryngotracheitis virus is phylogenetically distant from these two viruses and serves to underline similarity and diversity within the Alphaherpesvirinae read more ...