Caister Academic Press

Hendra and Nipah Virus

Bevan Sawatsky, Charlene Ranadheera, Hana M. Weingartl and Markus Czub
from: Animal Viruses: Molecular Biology (Edited by: Thomas C. Mettenleiter and Francisco Sobrino). Caister Academic Press, U.K. (2008)


Over the past decade, the previously unknown paramyxoviruses Hendra virus (HeV) and Nipah virus (NiV) have emerged in humans and livestock in Australia and Southeast Asia. Both viruses are contagious, highly virulent, and capable of infecting a number of mammalian species and causing potentially fatal disease. Due to the lack of a licensed vaccine or antiviral therapies, HeV and NiV are designated as biosafety level (BSL) 4 agents and are potential bioterrorist agents. The genomic structure of both viruses is that of a typical paramyxovirus. However, due to limited sequence homology and little immunological cross-reactivity with other paramyxoviruses, HeV and NiV have been classified into a new genus within the family Paramyxoviridae named Henipavirus read more ...
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