Caister Academic Press

Lanthanides in Methylotrophy

Authors: Elizabeth SkovranDepartment of Biological Sciences, San Jose State University, San Jose, CA, USA Charumathi RaghuramanDepartment of Biological Sciences, San Jose State University, San Jose, CA, USA Norma Cecilia Martinez-GomezDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
Abstract:
Open-access article
Lanthanides were previously thought to be biologically inert owing to their low solubility; however, they have recently been shown to strongly impact the metabolism of methylotrophic bacteria. Leading efforts in this emergent field have demonstrated far-reaching impacts of lanthanide metabolism in biology; from the identification of novel roles of enzymes and pathways dependent on lanthanide-chemistry to the control of transcriptional regulatory networks to the modification of microbial community interactions. Even further, the recent discovery of lanthanide-dependent enzymes associated with multi-carbon metabolism in both methylotrophs and non-methylotrophs alike suggests that lanthanide biochemistry may be more widespread than initially thought. Current efforts aim to understand how lanthanide chemistry and lanthanide-dependent enzymes affect numerous ecosystems and metabolic functions. These efforts will likely have a profound impact on biotechnological processes involving methylotrophic communities and the biologically mediated recovery of these critical metals from a variety of waste streams while redefining our understanding of a fundamental set of metals in biology.
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