Caister Academic Press

Peptide Signaling

Authors: Jeremy M. Yarwood
Abstract: The study of peptide signaling is yielding both fascinating and valuable information regarding bacterial biofilm development and helping to elucidate the disease processes caused by several human pathogens. Peptide signaling potentially impacts all stages of the biofilm "life-cycle" for many bacterial species, from attachment to maturation and detachment. While the particular roles of the signaling systems in biofilm formation varies among species, the implications of several phenomena, from natural transformation of streptococci to quorum sensing variant generation in staphylococci, may only be fully appreciated in the context of biofilms and cell-to-cell signaling. Understanding the mechanisms by which the peptide signaling systems exert their effects on biofilms may yield therapeutic strategies with limited, but important, uses.
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