Caister Academic Press

Biofilms of Salmonella enterica

Authors: Ute Römling, Devrim Pesen and Sima Yaron
Abstract: Salmonella enterica (S. enterica) can form multicellular structures, commonly called biofilms, on various occasions. Biofilms can be formed on diverse surfaces/interfaces such as at the epithelial cell layer of a vertebrate host, on plant surfaces, or on abiotic surfaces, at the air–liquid interface and on gallstones. In this way, S. enterica is thought to achieve environmental persistence, transmission, and colonization of host organisms. Characterization of biofilm formation at the molecular level revealed different types of biofilms that have common and distinct regulatory and structural components. The so-called "rdar morphotype", a multicellular behavior of S. enterica on agar plates is characterized by the expression of the master regulator CsgD, which controls expression of the extracellular matrix components curli fimbriae, the large surface-associated protein BapA, the exopolysaccharide cellulose and a capsular polysaccharide. Colonization of abiotic surfaces, plant surfaces and epithelial cell layers partly require the same factors as rdar morphotype formation, while the biofilm formed by Salmonella on gall stones seems to be substantially distinct from rdar morphotype formation.
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