Acanthamoeba: Biology and Pathogenesis
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Author: Naveed Khan Published: 2009 ISBN: 978-1-904455-43-1 Everything that is known about Acanthamoeba is critically reviewed and divided into easy-to-follow sections. The current state of research on genomics, molecular and cellular biology, life cycles, geographical distribution, role in ecosystem, morphology, motility, phylogenetics, genotyping, metabolism, regulation of morphogenesis, host-parasite interactions, the molecular and immunological basis of pathogenesis, methods of transmission, epidemiology, clinical manifestation, diagnosis, treatment, new target development and drug resistance, and much more. read more ... |
Figure from: Acanthamoeba Biology and Pathogenesis
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Section D. Figure 8. The model of Acanthamoeba granulomatous encephalitis. Acanthamoeba are thought to enter lungs via the nasal route. Next, amoebae traverse the lungs into the bloodstream, followed by haematogenous spread. Finally, Acanthamoeba cross the blood-brain barrier and enter into the central nervous system (CNS) to produce disease. It is noteworthy that Acanthamoeba may bypass the lower respiratory tract and directly enter into the bloodstream via skin lesions. The olfactory neuroepithelium may provide an alternative route of entry into the CNS.
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