Acanthamoeba: Biology and Pathogenesis
Author: Naveed Khan Published: 2009 ISBN: 978-1-904455-43-1 Everything that is known about Acanthamoeba is critically reviewed and divided into easy-to-follow sections. The current state of research on genomics, molecular and cellular biology, life cycles, geographical distribution, role in ecosystem, morphology, motility, phylogenetics, genotyping, metabolism, regulation of morphogenesis, host-parasite interactions, the molecular and immunological basis of pathogenesis, methods of transmission, epidemiology, clinical manifestation, diagnosis, treatment, new target development and drug resistance, and much more. read more ... |
Figure from: Acanthamoeba Biology and Pathogenesis
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Section A. Figure 14. Role of GTP cap in microtubule assembly. If tubulin concentration is high, tubulin-GTP is added to microtubule tip faster than the incorporated GTP can be hydrolyzed. The resulting GTP cap stabilizes the microtubule tip and promotes further growth. At low concentration, the rate of growth decreases, thereby allowing GTP hydrolysis but creating unstable tip that favours depolymerization.
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