Caister Academic Press

North American Plague Models of Enzootic Maintenance, Epizootic Spread, and Spatial and Temporal Distributions

Rebecca J. Eisen, Kenneth L. Gage and
from: Yersinia: Systems Biology and Control (Edited by: Elisabeth Carniel and B. Joseph Hinnebusch). Caister Academic Press, U.K. (2012)


Plague is a severe, primarily flea-borne, rodent-associated zoonosis caused by Yersinia pestis. The majority of human infections are associated with epizootic periods that are defined by rapid transmission in rodent populations. In this chapter, we highlight how modeling has been used to integrate field- and laboratory-derived data to provide insights into identifying when and where epizootics are most likely to occur, how Y. pestis is maintained during periods of apparent quiescence, what triggers a transition to the epizootic phase, and the forces that drive plague epizootics. Understanding these dynamics is critically important for targeting limited public health resources for surveillance, prevention and control, informing wildlife management decisions, and anticipating future disease trends in relation to changing climatic and land use patterns read more ...
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