Coordinated Regulation of Gene Expression in Vibrio cholerae
Rupak K. Bhadra and Bhabatosh Das
from: Vibrio cholerae: Genomics and Molecular Biology (Edited by: Shah M. Faruque and G. Balakrish Nair). Caister Academic Press, U.K. (2008)
Vibrio cholerae, the causative agent of the severe diarrhoeal disease cholera, has evolved with intricate signal transduction and gene regulatory systems to survive and grow under various environmental conditions. The virulence regulon of V. cholerae, which involves multiple genes working in a coordinated manner, represents a regulatory paradigm for extracellular bacterial pathogens. Availability of the whole genome sequence has allowed microarray based transcriptome analyses of V. cholerae cells isolated directly from cholera patients. Such studies indicate that quite a large number of genes are involved in the disease process and their expression pattern changes as the infection progresses. Further understanding of the process came with the recent discoveries of small noncoding RNAs and intracellular signal molecule c-di-GMP as modulators of gene expression in V. cholerae. Transcriptome analysis has also shed light on synchronized gene expression related to chitin utilization and development of natural competence when the organism exists in the natural aquatic environment. Thus, the survival, evolution and pathogenesis of V. cholerae appear to be controlled by several intricate overlapping regulatory circuits read more ...