Filamentous bacteriophages in Vibrio cholerae genetics and evolution
E. Fidelma Boyd
from: Vibrio cholerae: Genomics and Molecular Biology (Edited by: Shah M. Faruque and G. Balakrish Nair). Caister Academic Press, U.K. (2008)
The role of filamentous phages, particularly CTXΦ in Vibrio cholerae genetics and evolution are discussed. An overview of the CTXΦ genome structure and interaction with the V. cholerae host cell during the various stages of the lifecycle of CTXΦ are outlined. The evolution of CTXΦ is explored, and the co-evolution of pIIICTX and the TcpA, the major pilin protein of TCP the receptor for CTXΦ is examined. Seven diverse filamentous phages have been characterized from V. cholerae O1 and O139 serogroup isolates and these phages and their putative roles in V. cholerae biology are reviewed read more ...