RNA Vaccines for Infectious Diseases of Animals: A Future Trend
Laurel J. Gershwin
from: Veterinary Vaccines: Current Innovations and Future Trends (Edited by: Laurel J. Gershwin and Amelia R. Woolums). Caister Academic Press, U.K. (2020) Pages: 223-238.
Abstract
Future trends for veterinary vaccines must include mRNA vaccines. Vaccines consisting of mRNA that encodes a protective antigen from the pathogen of interest offer a new and exciting approach to development of veterinary immunoprophylaxis. The technique has several advantages over attenuated, inactivated, subunit, and viral vectored vaccines. Once the sequence of a candidate antigen is known a mRNA can be made. Cell culture and viral propagation is not a requirement for vaccine production. Thus these vaccines can be manufactured rapidly and once developed are not costly. These characteristics make mRNA vaccines a strong choice for development of newly emerging viruses for species of veterinary importance. Indeed at least one candidate vaccine for the COVID-19 currently in clinical trials is a mRNA vaccine. Herein the published work on candidate mRNA vaccines for human and zoonotic disease is described, including mechanisms of action and choices for delivery of the mRNA are discussed read more ...
