Linhui Wang and Jean C. Lee
from: Advanced Vaccine Research Methods for the Decade of Vaccines (Edited by: Fabio Bagnoli and Rino Rappuoli). Caister Academic Press, U.K. (2015) Pages: 425-448.
Development of an effective vaccine to prevent Staphylococcus aureus disease in humans continues to be a major challenge for the research community. There have been four phase III clinical trials aimed at proving efficacy with a single component vaccine or immunotherapeutic, but each has failed at different stages of development. Vaccines comprising multiple staphylococcal proteins and polysaccharides and vaccines aimed at eliciting a T cell response are currently being explored, but there is little agreement on the ideal formulation. Major limitations include our failure to identify convincing correlates of protective immunity to S. aureus, as well as less than optimal models of staphylococcal infection in rodents. Despite these challenges, there are new approaches and ongoing efforts by both industry and academic labs to design an effective vaccine to contain this formidable pathogen read more ...