Cancer Immunotherapy: The Road to Rejection
Peter E. Fecci, Christina Chen, Susanne Baumeister and Glenn Dranoff
from: Advanced Vaccine Research Methods for the Decade of Vaccines (Edited by: Fabio Bagnoli and Rino Rappuoli). Caister Academic Press, U.K. (2015) Pages: 359-386.
Immunotherapy continues to gain both momentum and legitimacy as a rational mode of cancer therapy. The idea that the immune system, if correctly manipulated, might be capable of surveying, identifying, and eradicating, in precise fashion, those cells that have mutant or newly expressed proteins en route to neoplastic growth patterns has long proved intriguing. This idea has been gradually shaped into a variety of immunotherapy approaches ranging from antibodies to cell transfers to vaccines. A large number of tumor types are also under study, including melanoma, glioma, lung, prostate, breast, head/neck, cervical, ovarian, pancreas, renal cell, colorectal cancers, and lymphoma. This chapter will review the current state, applications, adjuncts, and challenges to the successful immune-based treatment of cancer, emphasizing clinical trials read more ...