Caister Academic Press

Malaria Vaccine Development: Progress to Date

Kevin Marsh
from: Advanced Vaccine Research Methods for the Decade of Vaccines (Edited by: Fabio Bagnoli and Rino Rappuoli). Caister Academic Press, U.K. (2015) Pages: 273-304.


Malaria is a major global health problem with substantial morbidity and mortality. Some progress in reducing this burden has been made with existing malaria control measures and a vaccine would be an important addition. The malaria parasite is complex, presenting several thousand possible antigens expressed in various lifecycle stages. We examine the difficulties in translating the findings from immuno-epidemiology to vaccination strategies, and the difficulties in selecting an appropriate animal model. Despite the apparent complexity of the problem a partially successful vaccination approach has been progressed through to Phase III trials and a license application is expected. Furthermore whole parasite vaccination approaches appear highly effective in experimental challenge studies. Further improvements are expected as antigen selection and antigen delivery are optimized with rapid down-selection of approaches using in-vitro functional studies, global genetic parasite diversity, appropriately designed and interpreted animal models before proceeding to Controlled Human Malaria Infection studies and field trials. A highly effective malaria vaccine based on a multi-stage, multi component approach is technically feasible read more ...
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