Caister Academic Press

T Cell Inducing Vaccines

Sarah Gilbert
from: Advanced Vaccine Research Methods for the Decade of Vaccines (Edited by: Fabio Bagnoli and Rino Rappuoli). Caister Academic Press, U.K. (2015) Pages: 251-262.

Abstract

For some infectious pathogens a protective T cell response as well as or instead of a functional antibody response is necessary to protect against disease. The development of vaccines designed to induce T cell responses has been hampered by difficulties in finding appropriate technologies for measuring and characterizing the immune response as well as defining safe and highly immunogenic methods of vaccination. This chapter will review progress in both of these areas, and report on advances in development of vaccines for malaria, HIV, influenza, tuberculosis and cancer that rely on inducing T cell responses. Key publications are listed in Table 1 read more ...
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