New Frontiers in the Chemistry of Glycoconjugate Vaccines
David R. Bundle
from: Vaccine Design: Innovative Approaches and Novel Strategies (Edited by: Rino Rappuoli and Fabio Bagnoli). Caister Academic Press, U.K. (2011)
Abstract
Methods for single point attachment of polysaccharides and oligosaccharides to protein carriers and T-cell peptides are briefly reviewed with emphasis on contemporary approaches that involve synthetic oligosaccharides with linker or tether chemistry designed for compatibility with synthetic strategies. The synthesis and evaluation of conjugate vaccines designed to combat infectious bacterial and fungal diseases, as well as promising attempts to design and test therapeutic cancer vaccine are summarized. The prevailing dogma that protective B-cell epitopes should be comprised of 10-20 monosaccharides is confirmed for several experimental vaccines including those directed toward Shigell flexneri and Shigella dysenteriae. However, several small epitopes composed of 3-5 monosaccharide residues are sufficient to induce antibody against the whole organism and to confer protection read more ...
