Caister Academic Press

Cell Cycle and Developmental Regulation By Two-component Signaling Proteins in Caulobacter crescentus

Stephen C. Smith, Juan-Jesus Vicente and Kathleen R. Ryan
from: Two-Component Systems in Bacteria (Edited by: Roy Gross and Dagmar Beier). Caister Academic Press, U.K. (2012)


The intricate cell division and developmental cycle of the α-Proteobacterium Caulobacter crescentus has been studied for four decades. During that time, elegant genetic screens and comprehensive post-genomic methods have uncovered a branched network of two-component signaling proteins that orchestrates Caulobacter cell cycle progression and morphological development. In addition to yielding the first and most detailed picture of bacterial cell cycle control, Caulobacter studies have revealed novel ways in which two-component proteins generate cellular outputs, interact with each other, and are themselves regulated read more ...
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