Caister Academic Press

Molecular Mechanism of Bacterial Two-component Signal Transduction Networks via Connectors

Yoko Eguchi, Eiji Ishii and Ryutaro Utsumi
from: Two-Component Systems in Bacteria (Edited by: Roy Gross and Dagmar Beier). Caister Academic Press, U.K. (2012)


Two-component system (TCS) connectors are proteins that connect different TCSs. By connecting TCSs, they integrate the signals to which each TCS responds, and enable the cell to respond flexibly to the fluctuating environment. A number of auxiliary proteins of TCSs, which bind to the components of TCSs for modification, have been reported. When the expression of such TCS auxiliary proteins is controlled by a TCS, it connects the two TCSs and is termed a TCS connector. Several TCS connectors have been identified in Salmonella and Escherichia coli. In this chapter, we describe how these TCS connectors and the TCSs they connect form a signal transduction network. TCS connectors in Bacillus subtilis as well as TCS auxiliary proteins as candidates of TCS connectors are also introduced. We have clarified a small portion of the predicted two-component signal transduction network as an initial description of the complicated signal network that exists in bacteria read more ...
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