Juliane Bubeck Wardenburg, James Whisstock and Rodney K. Tweten
from: Bacterial Toxins: Genetics, Cellular Biology and Practical Applications (Edited by: Thomas Proft). Caister Academic Press, U.K. (2013)
Bacterial pore forming protein toxins are widespread among bacterial pathogens and opportunistic pathogens. Their roles in disease progression are varied and complex. In this review the cholesterol dependent cytolysins (CDCs) and the related membrane attack complex/perforin (MACPF) protein families, as well as Staphylococcus aureus α-hemolysin will be discussed. These pore forming proteins exhibit prominent structural and mechanistic features that are paradigms for other pore-forming proteins. In this review we will focus on their structure and mechanisms of action and how they relate to their contribution(s) to pathogenesis read more ...