Interplay of Ubiquitination and SUMOylation with miRNAs
Yashika Agrawal and Manas Kumar Santra
from: SUMOylation and Ubiquitination: Current and Emerging Concepts (Edited by: Van G. Wilson). Caister Academic Press, U.K. (2019) Pages: 217-230.
Abstract
A myriad of processes occurring in each individual cell govern the functions of tissues and the overall activity of multicellular organisms. Stringent and precise multilevel control of these cellular pathway components dictates the normal functioning of cells. This control, to maintain the homeostasis in the cells, is exercised at various levels including transcription, post-transcription, translation and post-translation. miRNAs have emerged as major players regulating the post-transcriptional events in the cells, whereas ubiquitination and sumoylation are among the major post-translational events. The following sections in this chapter will discuss miRNAs, namely their synthesis and functions, the processes of ubiquitination and sumoylation and how these different level modifications crosstalk with each other in order to regulate the normal and diseased states of individuals read more ...
