Interplay of the Ubiquitin Proteasome System and Mitochondria in Protein Homeostasis
Mafalda Escobar-Henriques, Selver Altin and Fabian den Brave
from: SUMOylation and Ubiquitination: Current and Emerging Concepts (Edited by: Van G. Wilson). Caister Academic Press, U.K. (2019) Pages: 193-216.
Abstract
Eukaryotic cells are subdivided into membrane-bound compartments specialised in different cellular functions and requiring dedicated sets of proteins. Mitochondria are essential organelles whose proper functioning is critical for cellular health. Although cells developed compartment-specific mechanisms for protein quality control, chaperones and ubiquitin are generally required for maintaining cellular proteostasis. Proteotoxic stress is signalled from one compartment into another to adjust the cellular stress response. Moreover, transport of misfolded proteins between different compartments can buffer local defects in protein quality control. Mitochondria are special organelles in that they possess an own expression, folding and proteolytic machinery, of bacterial origin, which do not have ubiquitin. Nevertheless, the importance of extensive crosstalk between mitochondria and other subcellular compartments is increasingly clear. Here, we will present local quality control mechanisms and discuss how cellular proteostasis is affected by the interplay between mitochondria and the ubiquitin proteasome system.
