Genomics of Streptomyces Cytochromes P450
David C. Lamb, Bin Zhao, F. Peter Guengerich, Steven L. Kelly and Michael R. Waterman
from: Streptomyces: Molecular Biology and Biotechnology (Edited by: Paul Dyson). Caister Academic Press, U.K. (2011)
In the present chapter, a review of the current status regarding the molecular biology and biochemistry of streptomycete cytochromes P450 (CYPs) will be presented. Emphasis will be placed upon CYPs with novel functions and identifiying the roles of CYPs in the four sequenced and publically available streptomycete genomes: Streptomyces coelicolor, Streptomyces avermitilis, Streptomyces griseus, and Streptomyces scabies. Additionally, the first detailed analysis of the CYP complement of a Streptomyces genome is being undertaken in the laboratories of the authors and colleagues. A summary of these findings will be presented. Finally, discussion on how new drugs might be generated from Streptomyces by modifying the structure of specific CYPs, as well as thoughts regarding actinomycete P450 research in the future, will be outlined read more ...