Immune Response to Staphylococcus aureus
Aisling F. Brown and Rachel M. McLoughlin
from: Staphylococcus: Genetics and Physiology (Edited by: Greg A. Somerville). Caister Academic Press, U.K. (2016) Pages: 335-388.
Staphylococcus aureus can act as either a harmless commensal or a potentially lethal pathogen. Disease is just one of a number of possible outcomes of host-microbe interactions. It is the interplay between both host and microbial factors that determines whether or not disease occurs and its severity. Here, we outline the main functions and elements of the host immune system and consider how they interact with S. aureus to shape clinical outcomes. We further discuss how the organism seeks to evade host immune mechanisms and review the immunodeficiency states that render certain hosts susceptible to S. aureus infection. Finally, we review the status of anti-S. aureus vaccine development and examine how we might modulate the immune response in order to improve the outcome of infection read more ...