Physiological Proteomics of Staphylococcus aureus: From the Protein Inventory to Stress Physiology and In Vivo adaptation
Susanne Engelmann, Stephan Fuchs and Michael Hecker
from: Staphylococcus: Genetics and Physiology (Edited by: Greg A. Somerville). Caister Academic Press, U.K. (2016) Pages: 119-132.
Here we present the different facets of proteomics turning it into a valuable tool for a more comprehensive understanding of metabolism and stress and starvation responses of Staphylococcus aureus. Relying on a combination of gel-based and gel-free proteomics procedures, new fields in staphylococci physiology such as phosphoproteomics, protein damage or proteolysis on a proteome wide scale are addressed. Finally, we show that stress/starvation proteomics signature libraries are essential diagnostic tools for the analysis of the physiological state of S. aureus cells under both in vitro and in vivo conditions read more ...