Staphylococcus aureus Metabolism and Physiology
Greg A. Somerville
from: Staphylococcus: Genetics and Physiology (Edited by: Greg A. Somerville). Caister Academic Press, U.K. (2016) Pages: 107-118.
All living organisms require endogenous and/or exogenous sources of biosynthetic precursors (e.g., nucleic acids, amino acids, carbohydrates, etc.) for polymerizing and assembly reactions that make DNA, RNA, proteins, and everything else required for life. In Staphylococcus aureus, the de novo synthesis of biosynthetic precursors requires thirteen biosynthetic intermediates (e.g., glucose-6-phosphate and oxaloacetate) and the coordinated action of numerous enzymes. The life-cycle of S. aureus is such that its environment is in a near constant state of flux. This flux has important implications because enzyme activity is altered in response to co-factor, substrate, and product availability, pH, temperature, post-translational modifications, and many other environmental and nutritional factors. In other words, changes in the environment precipitate changes in enzymatic activity, which alters the availability of biosynthetic precursors and the ability to synthesize cellular components. Understanding how environmental changes alter metabolism, begins with an understanding of metabolism read more ...