Staphylococcus epidermidis and other Coagulase-Negative Staphylococci
Shu Yeong Queck and Michael Otto
from: Staphylococcus: Molecular Genetics (Edited by: Jodi Lindsay). Caister Academic Press, U.K. (2008)
Over the last two decades, coagulase-negative staphylococci with the most important species Staphylococcus epidermidis have been recognized as important opportunistic pathogens. These abundant commensal organisms of the human skin and mucous membranes may cause serious infections, predominantly as biofilm-associated infections on indwelling medical devices, and are now the most frequent cause of hospital-acquired infections. More recently, the elucidation of the genomes of S. epidermidis and other coagulase-negative staphylococci, and a more pronounced interest in the molecular biology of especially S. epidermidis and its interaction with human host defenses, have provided more detailed insight into how these bacteria cause human disease. We have learned that, although definitely more limited, the repertoire and also the regulation of virulence factors in S. epidermidis may differ significantly from S. aureus. Furthermore, as a result of the increasing volume and depth of research on this pathogen, some findings have been obtained in S. epidermidis that have paradigmatic character for many staphylococci and Gram-positive pathogens read more ...