Mechanisms of β-Lactam and Glycopeptide Resistance in Staphylococcus aureus
Mariana G. Pinho
from: Staphylococcus: Molecular Genetics (Edited by: Jodi Lindsay). Caister Academic Press, U.K. (2008)
Worldwide spread of multidrug resistant Staphylococcus aureus poses serious challenges to chemotherapy, which were recently emphasized by the appearance of vancomycin resistant S. aureus (VRSA) strains. Vancomycin has become the standard therapeutic agent against methicillin-resistant S. aureus (MRSA) strains, for which the choice of treatment is limited by the accumulation of a number of other antibiotic resistance markers acquired during recent evolution of the staphylococcal genome. This chapter summarizes specific resistance mechanisms against β-lactam and glycopeptide antibiotics, as well as the mechanisms for synergism between these two classes of antibiotics, focusing on the molecular aspects as well as on the whole-cell response to the presence of antibiotics that target cell wall synthesis read more ...