Caister Academic Press

Entry of a Segmented dsRNA Vrus Into the Bacterial Cell

Minna M. Poranen and Dennis H. Bamford
from: Segmented Double-stranded RNA Viruses: Structure and Molecular Biology (Edited by: John T. Patton). Caister Academic Press, U.K. (2008)


The entry pathway of bacterial dsRNA viruses of the family Cystoviridae is a multi-step process, which does not resemble the entry mechanisms employed by other bacteriophages, rather having features common with viruses infecting animal cells. As the virion passes the multi-layered cell envelope of its gram-negative host the structural layers of the virion are removed in a stepwise manner. After adsorption to the receptor the entry is initiated by fusion between the virus membrane and the host outer membrane, followed by peptidoglycan penetration and finally by endocytic-like internalisation of the viral particle. Spike protein P3, fusion protein P6, lytic enzyme P5, and NC surface shell protein P8 are exposed one by one to perform their role and to direct the viral core to its destination, the host cell cytosol. The energetic state of the host cell plays an important role during the entry of dsRNA phage f6 read more ...
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