Caister Academic Press

Rotavirus Structure

Xiaofang Jiang, Sue E. Crawford, Mary K. Estes and B. V. Venkataram Prasad
from: Segmented Double-stranded RNA Viruses: Structure and Molecular Biology (Edited by: John T. Patton). Caister Academic Press, U.K. (2008)


This chapter describes our current understanding of the rotavirus structure and how structural studies have provided some insights into capsid associated functions including cell entry, antibody neutralization, trypsin-enhanced infectivity and endogenous transcription. In the last two decades several dsRNA viruses have been structurally characterized using cryo-EM and X-ray crystallographic techniques. Despite some distinctive structural features reflecting their host specifies, these studies have revealed several common mechanistic themes particularly in regard to endogenous transcription of the genome. The possible evolutionary implications of the common features among these viruses are also discussed read more ...
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