Roles of miRNAs in Cancers Associated with Human Tumor Viruses
Xianzhi Lin, Deguang Liang and and Ke Lan
from: Applied RNAi: From Fundamental Research to Therapeutic Applications (Edited by: Patrick Arbuthnot and Marc S. Weinberg). Caister Academic Press, U.K. (2014)
Considerable accumulated lines of evidence have shown that microRNAs (miRNAs) play important roles in regulating gene expression in many critical physiological conditions as well as disease progression. The regulation of gene expression by miRNAs could affect mRNA cleavage, mRNA degradation, and inhibition of mRNA translation. Seven tumor viruses have so far been identified in humans. The infection of the host by these human tumor viruses could result in the development of many severe diseases or even several malignant ones like cancers. These human tumor viruses have taken advantage of the pathways that cellular miRNAs have been involved in by encoding their own viral miRNAs and/or hijacking host miRNAs. In this chapter, we will review recent advances on the roles miRNAs played in cancers associated with human tumor viruses, with the focus on human tumorigenic herpesviruses read more ...