HCV and the Interaction with miR-122 in the Liver
Gabriele Fuchs and Cara T. Pager
from: RNA Interference and Viruses: Current Innovations and Future Trends (Edited by: Miguel Angel Martínez). Caister Academic Press, U.K. (2010)
MicroRNAs (miRNA) are endogenous non-coding RNA molecules, typically 21 nucleotides in length that can inhibit target gene expression when bound to 3' untranslated regions in target mRNAs. In this review we summarize how miRNAs are generated, how miRNA-target interactions occur and the different outcomes of these interactions. In detail, we describe the unusual interaction between the liver-specific miRNA miR-122 and Hepatitis C virus (HCV) RNA, and review what is known about the mechanism by which miR-122 modulates HCV gene expression. Furthermore, we discuss the role of miR-122 in the liver, and how therapeutic approaches that alter miR-122 levels can influence HCV replication and hepatocarcinogenesis read more ...