Bovine Papillomaviruses and Equine Sarcoids
Lubna Nasir and Stuart W.J. Reid
from: Papillomavirus Research: From Natural History To Vaccines and Beyond (Edited by: M. Saveria Campo). Caister Academic Press, U.K. (2006)
Equine sarcoids are locally aggressive, non regressing, fibroblastic skin tumours representing the most common dermatological neoplasm reported in equidae. It is widely accepted that the Bovine Papillomavirus (BPV) types 1/2 are associated with the pathogenesis of sarcoid disease. The majority of lesions contain detectable viral nucleic acids and express the BPV 1/2 major transforming protein, E5, but appear to be non-productive for infectious virions. Here we review the evidence supporting association of sarcoids with bovine papillomavirus (BPV) and the nature of the infecting viral genomes and consider the practical implications of BPV infection for diagnostic and therapeutic purposes read more ...