Late Events in the Life Cycle of Human Papillomaviruses
Sheila V. Graham
from: Papillomavirus Research: From Natural History To Vaccines and Beyond (Edited by: M. Saveria Campo). Caister Academic Press, U.K. (2006)
Late events in the life cycle of human papillomaviruses (HPVs) include vegetative viral DNA replication, capsid protein production, virion assembly and virus transmission. Such late events are tightly linked to differentiation of the epithelium that the virus infects. The molecular mechanisms underpinning these events are not completely understood as yet but clearly involve contributions from both the host cell and the virus genome itself. This chapter summarises the main late events in the infectious life cycle. Current knowledge of virus late gene expression and its regulation is detailed. In particular, the interplay between viral early and late promoters and the important role of negative regulatory elements that reside in viral late RNAs are discussed. Finally, the putative trafficking and assembly pathways involving host cell and viral gene products that result in production of infectious virus particles are outlined read more ...