The Papillomavirus Transcription/Replication Factor E2: Structure, Function, Cancer and Therapy
Iain M. Morgan and Mary M. Donaldson
from: Papillomavirus Research: From Natural History To Vaccines and Beyond (Edited by: M. Saveria Campo). Caister Academic Press, U.K. (2006)
As with all papillomavirus (PV) proteins, E2 has been studied in a number of systems with BPV1 providing the original paradigm. Extensive work has also been carried out investigating HPV 16, 18, 11, 6, and 31 E2 proteins amongst others. This chapter will begin with an introduction to the E2 protein and its general structure and function and will then go on to discuss more specific roles. The role of E2 and interacting partners in viral replication and transcription will be discussed, as well as their role in segregating viral genomes and regulating the host cell cycle. Finally, the status of E2 expression in cancer will be discussed and also strategies for therapeutically targeting the E2 protein for the treatment of PV related diseases read more ...