Entamoeba histolytica Genomic Analyses
Upinder Singh and Gretchen M. Ehrenkaufer
from: Anaerobic Parasitic Protozoa: Genomics and Molecular Biology (Edited by: C. Graham Clark, Patricia J. Johnson and Rodney D. Adam). Caister Academic Press, U.K. (2010)
The sequencing of the Entamoeba histolytica genome, as well as the development of genome-wide techniques to allow study of gene expression, has led to many advances in our understanding of the biology of this parasite. In this chapter, we examine recent work using genomic technologies (DNA microarrays and proteomics) to study important aspects of amebic biology, including pathogenesis, host interaction, phagocytosis, stage conversion, responses to stressful stimuli, and mechanisms of gene regulation. The studies described in this chapter identify pathways involved in regulating major functions in this important human pathogen read more ...