Targeted Proteomics for Chronic Lymphocytic Leukemia
Rafael Góngora, Paula Díez, Nieves Ibarrola, Rosa M. Dégano, Alberto Orfao and Manuel Fuentes
from: Proteomics: Targeted Technology, Innovations and Applications (Edited by: Manuel Fuentes and Joshua LaBaer). Caister Academic Press, U.K. (2014)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. It is a blood and bone marrow disease that progresses slowly. Traditionally, flow cytometry has been the diagnosis tool of choice due to the wide knowledge in markers field. Other strategies, such as fluorescent in situ hybridisation, have allowed chromosomal studies related to CLL. Numerous markers such as Zap70 protein or CD38 have been recently established as possible identifiers of the disease. For this, the need of proteomics approaches is evident. In this chapter we introduce basic information about the disease and its features, as well as the most relevant strategies in proteomics area leading to a better understanding of CLL read more ...