Caister Academic Press

Bovine Spongiform Encephalopathy and Scrapie

Takashi Yokoyama
from: Prions: Current Progress in Advanced Research (Edited by: Akikazu Sakudo and Takashi Onodera). Caister Academic Press, U.K. (2013)


Bovine spongiform encephalopathy (BSE) emerged more than 2 decades ago, and until today, over 190,000 heads of cattle have been diagnosed. An effective feed ban program has diminished the outbreak worldwide; however, different phenotypes of BSE (atypical BSEs) have emerged. Additionally, a different phenotype of scrapie (atypical scrapie) was reported in 1998. The prevalence of these diseases is low and suggests the possibility that they are spontaneous forms of prion diseases. The decline in BSE outbreaks has led to discussion for the withdrawal of some control programs. However, despite their unknown origin, the transmissibility of these atypical animal prion diseases has been demonstrated. Pre-emptive measures are necessary in order to prevent future outbreaks of atypical prion diseases in animals read more ...
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