Effect of Microglial Inflammation in Prion Disease
Yasuhisa Ano, Akikazu Sakudo and Takashi Onodera
from: Prions: Current Progress in Advanced Research (Edited by: Akikazu Sakudo and Takashi Onodera). Caister Academic Press, U.K. (2013)
Prion diseases are a group of transmissible fatal neurodegenerative disorders. Neuropathological features of prion diseases include neuronal vacuolation, neuronal loss, astrogliosis, and accumulation of activated microglial cells in affected brain areas. Recent studies have indicated that microglia may play a role in the pathogenesis of prion diseases. Chemokine receptor (CXCR3) expressed in microglia and microglial inflammasome activated by prion infection is important in the etiology of CNS pathologies. pathologies. The functions of microglia in this disease are discussed in this review read more ...