Caister Academic Press

Bovine Spongiform Encephalopathy and Scrapie

Takashi Yokoyama and Yoshifumi Iwamaru
from: Prions: Current Progress in Advanced Research (Second Edition) (Edited by: Akikazu Sakudo and Takashi Onodera). Caister Academic Press, U.K. (2019) Pages: 95-114.


Bovine spongiform encephalopathy (BSE) emerged more than three decades ago, and over 190,000 head of cattle have been diagnosed. An effective feed-ban programme has diminished the outbreak worldwide. Although the decline in BSE outbreaks has led to discussions for the withdrawal of some control programmes, different phenotypes of BSE (atypical BSEs) have emerged. Additionally, a different phenotype of scrapie (atypical scrapie) was reported in 1998. The prevalence of these atypical diseases is low and suggests the possibility that they are spontaneous forms of prion diseases. Despite their unknown origin, the transmissibility of these atypical animal prion diseases has been demonstrated read more ...
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