Ralstonia solanacearum and Bacterial Wilt in the Postgenomics Era
from: Plant Pathogenic Bacteria: Genomics and Molecular Biology (Edited by: Robert W. Jackson). Caister Academic Press, U.K. (2009)
The first Ralstonia solanacearum GMI1000 genome sequence was completed in 2002. This work paved the way for an enhanced understanding of the molecular genetics of this important plant pathogen. The availability of a fully annotated genome sequence made it possible to further our understanding of gene expression in planta and led to the discovery of important nuances in virulence gene regulatory cascades. Moreover, analysis of the more recently sequenced Race 3 biovar 2 strain, UW551, made comparative genomics possible. Other recent advances stemming from the genomic profile of R. solanacearum has led to an appreciation of this pathogen as a species complex, with a rich evolutionary history as well as the discovery and molecular dissection of a lysogenic bacteriophage that contributed to virulence on tobacco. Now that the genome is available, progress towards a more comprehensive study of the life cycle of this successful soil inhabitant and deadly plant pathogen can be made read more ...