Foot-and-Mouth Disease Virus
Francisco Sobrino, F. Caridi, R. Cañas-Arranz and M. Rodríguez-Pulido
from: Porcine Viruses: From Pathogenesis to Strategies for Control (Edited by: Hovakim Zakaryan). Caister Academic Press, U.K. (2019) Pages: 43-80.
Foot-and-mouth disease virus (FMDV) is the prototypic member of the Aphthovirus genus within the Picornaviridae family. This virus causes an acute systemic vesicular disease, foot-and-mouth disease (FMD), which affects livestock worldwide and causes one of the most feared animal diseases. Here we have addressed different aspects dealing with the biology of this highly variable and transmissible virus that are relevant to understand the viral infectious cycle, including its genome organization, its control of gene expression, the proteins encoded by the FMDV RNA and their known functions, as well as the role they play on cell entry and virus replication and pathogenesis. The characteristics of virus particles and the innate and adaptive responses elicited by this virus are also discussed, as well as current and new strategies for FMD control by vaccination and other antiviral strategies. This chapter also addresses the lesions and clinical signs FMD produce, the current approaches for virus diagnosis and characterization, as well as an overview regarding FMDV control and epidemiology read more ...