Therapies Directed at Pseudomonas aeruginosa Polysaccharides
Joanna B. Goldberg
from: Bacterial Polysaccharides: Current Innovations and Future Trends (Edited by: Matthias Ullrich). Caister Academic Press, U.K. (2009)
Given the critical importance of Pseudomonas aeruginosa as an opportunistic pathogen, it is necessary to consider novel targets for therapeutic development. This is especially true as this bacterium is naturally resistant to many antimicrobials and with the over use of antibiotics has become resistant to those it was once sensitive. Thus, there is a real need for new drugs and approaches to combat the myriad of diseases caused by this pathogen. Polysaccharides would appear to be suitable candidates in this regard. They are generally the outermost molecules on the surface of P. aeruginosa. Some have roles in adherence and/or biofilm formation. Other polysaccharides are considered virulence factors and are immunodominant antigens. Thus, this group of molecules would seem ideal for the development of therapeutic interventions. Unfortunately the identification of reagents to specifically inhibit polysaccharides has lagged far behind the obvious need for such drugs read more ...