Genetics and Regulation of Bacterial Polysaccharide Expression in Human Pathogenic Bacteria
David Corbett and Ian S. Roberts
from: Bacterial Polysaccharides: Current Innovations and Future Trends (Edited by: Matthias Ullrich). Caister Academic Press, U.K. (2009)
The presentation of a polysaccharide capsule on the cell surface is a common feature of many bacteria. The presence of a polysaccharide capsule mediates interactions between the bacterium and its immediate environment. As such, regulation of capsule expression will be vital in the survival of bacteria in new environments, as will moderating capsule expression in response to local changes in the environment as a consequence of bacterial growth. This ability to regulate capsule expression is particularly important for pathogenic bacteria where the local environment will change as a consequence of the host response to infection and where more or less capsule expression will dictate the likely survival of the bacteria in a hostile environment. In this chapter we discuss the regulation of capsule gene expression in a number of pathogenic bacteria and describe the regulation of Group 2 capsule gene expression in Escherichia coli in detail read more ...