Caister Academic Press

Virus Particles and the Uses of Such Particles in Bio- and Nanotechnology

George P. Lomonossoff
from: Recent Advances in Plant Virology (Edited by: Carole Caranta, Miguel A. Aranda, Mark Tepfer and J.J. Lopez-Moya). Caister Academic Press, U.K. (2011)


The capsids of most plant viruses are simple and robust structures consisting of multiple copies of one or a few types of protein subunit arranged with either icosahedral or helical symmetry. The capsids can be produced in large quantities either by the infection of plants or by the expression of the subunit(s) in a variety of heterologous systems. In view of their relative simplicity and ease of production, plant virus particles or virus-like particles (VLPs) have attracted much interest over the past 20 years for applications in both bio- and nanotechnology. As result, plant virus particles have been subjected to both genetic and chemical modification, have been used to encapsulate foreign material and have, themselves, been incorporated into supramolecular structures. This chapter reviews the various ways in which have been exploited over the past two decades read more ...
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