MAP Kinase Pathways in Pathogenic Fungi: Elements, Roles and Interactions
David M. Arana, Rebeca Alonso-Monge, Elvira Román, César Nombela and Jesús Pla
from: Pathogenic Fungi: Insights in Molecular Biology (Edited by: Gioconda San-Blas and Richard A. Calderone). Caister Academic Press, U.K. (2008)
Signal transduction pathways are essential mechanisms used by all living cells to sense and transmit the information from external environment to the cell. For pathogenic fungi, they are essential mechanisms that transmit signals from a continuously host changing environment to the nucleus, where a response normally takes place. This adaptive response is crucial for the pathogen, as a failure to trigger it may result in elimination of the microbe from the host. Fungal signalling pathways are very diverse, and comprise MAPK pathways, cAMP-dependent protein kinase pathway (PKA pathway), calcium mediated signalling, Ras1 signalling and lipid mediated signalling among others, all of them closely interrelated. We aim to review here the main signalling pathways both in Candida albicans and Crypptococcus neoformans, two important human fungal pathogens, with special emphasis in the MAPK signalling and their relations with other adaptive mechanisms. The knowledge of such processes is important not only as a relevant aspect of modern biology but also as it may provides clues for the development of novel therapeutic strategies to fight fungal infections read more ...