Regulatory Networks in the Host-fungal Pathogen Interactions
L. Fernandes, A.L. Bocca, A.M. Ribeiro, S.S. Silva, H.C. Paes, A.C. Amaral, V.L.P. Polez, N.F. Martins, C.M.A. Soares, and M.S.S. Felipe
from: Pathogenic Fungi: Insights in Molecular Biology (Edited by: Gioconda San-Blas and Richard A. Calderone). Caister Academic Press, U.K. (2008)
The host innate immune response is critical for protection against infection. Macrophages and neutrophils mainly participate in this response, producing and releasing cytokines and chemokines. In addition, they present microbial antigens to lymphocytes, leading to the development of a highly specific immune response. Receptors are required for detection of microbial components that trigger signaling pathways to activate the host immune response. On the other hand, sensing and responding to the environment is required for fungal survival. Fungi have sophisticated and conserved signaling cascades to sense and respond to different types of stress including osmotic shock, temperature, oxidative or nitrosative damage. This review focuses on the main pathways that host cells use to recognize, interact and respond to fungal pathogens and also highlights the cascades that regulate environmental responses by the most studied human fungal pathogens read more ...